Antiepileptic Drugs as Teratogens: The Mechanism Remains a Mystery

P 146: The Best New Antiepileptic Drugs to Prevent Orofacial Malformations as Side Effects of Antiepileptic Drugs

Mothers exposed to Antiepileptic drugs (AEDs) are at high risk to born babies with orofacial malformations such as cleft lips. About 9 percent of congenital abnormalities in babies of mothers with epilepsy relates to orofacial abnormalities. Maintaining safe antiepileptic drugs for millions of mothers with epilepsy is very important. Researches show that new AEDs have less side effects than the...

[Mechanism of action of antiepileptic drugs].

Antiepileptic drugs (DAEs) act through different mechanisms of action: increase in central inhibition, inhibition of excitatorios mechanisms and modification of the excitability through their action on the ionic channels. Epilepsy is characterized by an abnormal and hypersynchronic unloading of a neuronal population. The activity of numerous drugs is associated to increase in gabaergic activity...

Common Mechanism for Teratogenicity of Antiepileptic Drugs

Azarbayjani, F. 2001. Common mechanism for teratogenicity of antiepileptic drugs. Drug induced embryonic arrhythmia and hypoxia-reoxygenation damage. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculy of Pharmacy 253. 54 pp. Uppsala.

The anti-McCollough effect: the mystery remains.

Astrocytes as new targets for antiepileptic drugs

Epilepsy is a disorder of the brain characterised by un-provoked, recurrent seizures and affects about 1% of the population worldwide. A deeper understanding of the cellular basis of the epilepsies would be essential for the identification of novel targets for therapeutic intervention. Since neuronal hyperexcitation and hypersynchronization are hallmarks of epilepsy, the search for new antiepil...